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Neuronal hypoglycolysis sustains body health
Neurons have a high energy cost mainly sustained by glucose, but paradoxically present a weak glycolysis. This fact is now shown to account for healthy bioenergetics, reduced mitochondrial redox stress and whole-body fitness. Mice with high glycolytic rates in neurons present impaired autophagy, cognitive defects and metabolic-like syndrome.
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Weak neuronal glycolysis sustains cognition and organismal fitness
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Adipose tissue as a linchpin of organismal ageing
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Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism
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Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation