Mechanisms of RNA processing and splicing
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
Cryo-electron microscopy (cryo-EM) imaging of DNA replication origin activation explains the role of Mcm10, a minichromosome maintenance (MCM) protein homolog, during initiation. Mcm10 acts as a wedge to split the two MCM hexamers of the activated replicative helicase. Diverging replication forks are then established, with changes in the MCM hexamers that promote the topological separation of two DNA strands.