Records of Natural Products
A scientific open access journal in the field of natural products.LATEST ARTICLES
Phytochemistry and Pharmacology of Genus Cercis: A Review
The genus Cercis, belonging to the Fabaceae family, is widely distributed in China and traditionally employed in Chinese medicine to treat various disorders, like irregular menstruation, pain, cough and carbuncle swelling. Despite the availability of numerous scientific studies on this genus, reviews that comprehensively cover its phytochemistry and pharmacology remain limited. This review aims to systematically consolidate the scientific literature on the phytochemistry and pharmacology of eight Cercis species, retrieved from databases like PubMed, Web of Science, SciFinder, Google Scholar, and the China National Knowledge Infrastructure platform. Based on a thorough analysis of the literature, more than 100 compounds have been identified from Cercis species, including flavonoids, phenols, terpenoids, lignins, dibenz[b,f]oxepins and others. Extracts and chemical constituents derived from Cercis species exhibite significant antioxidant, analgesic, anti-inflammatory, antitumor, antibacterial activities. These findings contribute to a deeper understanding of the medicinal potential of Cercis species and their potential applications in healthcare.
DOI http://doi.org/10.25135/rnp.458.2404.3190 Keywords Cercis phytochemistry pharmacology bioactivity flavonoid Available online: May 20, 2024 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.In vitro α-Glucosidase inhibitors of Polyscias serrata Roots in a Parallel Study of Network Pharmacology
Nine known compounds were isolated from the P. serrata roots and showed promising inhibitory activity against α-glucosidase. The molecular docking study of them was exhibited the 4-hydroxyl group in the aromatic ring of benzoic acid derivatives improves the bioactivity. Network pharmacology was performed to investigate the molecular mechanisms of isolated compounds and suggested that the insulin resistance pathway would be a primary mechanism of action. This is the first time the α-glucosidase inhibitors of P. serrata roots were reported.
DOI http://doi.org/10.25135/rnp.457.2401.3038 Keywords Polyscias serrata α-glucosidase inhibitor molecular docking network pharmacology Available online: April 30, 2024 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.A New Sterol-Related Metabolite from the Soft Coral Capnella imbricata
Exploratory research was carried out on the ethyl acetate extract derived from the soft coral Capnella imbricata, sourced from the southeastern waters of Taiwan. This investigation yielded the isolation of three sterol-related compounds (1–3). Among these compounds, one previously unidentified metabolite, designated as 4β-hydroxy-24-methylene-5-cholesten-7-one (1), was discovered, along with two known metabolites, namely, 3β-hydroxy-24-methylene-5-cholesten-7-one (2) and gorgostan-5,25-dien-3β-ol (3). The structures of these isolated metabolites were determined through comprehensive spectroscopic analyses. Furthermore, the relative stereochemistry of metabolite 3 was established for the first time in this study using single-crystal X-ray diffraction analysis. The potential anti-inflammatory properties of metabolites 1–3 were evaluated by investigating their ability to suppress the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells.
DOI http://doi.org/10.25135/rnp.455.2402.3141 Keywords Capnella imbricata Sterol X-ray iNOS COX-2 Available online: April 30, 2024 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.Structure Characterization and Anti-tumor Activity of Polysaccharides from Rohdea chinensis
Three crude polysaccharides of RCP-A, B, and C were derived from the rhizome of Rohdea chinensis by means of hot water extraction, gradient ethanol precipitation and dialysis. Three different polysaccharides of RCP-C1-1, RCP-C1-2, and RCP-C1-3 were isolated using cellulose DEAE-52 and Sephadex G-200 chromatography from RCP-C. The average molecular weights of RCP-C1-1, RCP-C1-2, and RCP-C1-3 were measured as 1.51×104, 1.06×104, and 4.86×103 by means of MALDI-TOF MS and UHPGC, respectively. All three polysaccharides were found to consist of D-fructose and D-glucose following hydrolysis and comparison with literature data. Based on FT-IR and NMR analysis, the polysaccharides were identified as inulin-type fructans, with their backbone composed of α-D-glucopyranosyl-(1→2)-(β-D-fructofuranosyl)n-(1→2)-β-D-fructofuranoside (nRCP-C1-1=79, nRCP-C1-2=58, nRCP-C1-3=27). The anti-tumor activity of the polysaccharides (RCP-A, B, and C) was evaluated in H22 tumor-bearing mice. The results suggested that the polysaccharides (RCP-A, RCP-B, and RCP-C) inhibited the growth of H22 hepatocellular. Further, the treated groups of RCP-A, RCP-B, and RCP-C exhibited improvements in body weight as well as spleen/thymus indexes in H22 tumor-bearing mice.
DOI http://doi.org/10.25135/rnp.454.2403.3165 Keywords Rohdea chinensis polysaccharides anti-tumor activity inulin-type fructans Available online: April 30, 2024 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.